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PRIMA-1

Cayman Chemical Item Number 63520

(CAS 5608-24-2)

PRIMA-1 (CAS 5608-24-2)

See more	Transcription Factors (23) Cancer (606)

Description

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.¹ It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.

1 Bykov, V.J.N., Issaeva, N., Shilov, A., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 8(3) 282-288 (2002).

Formal Name	2,2-bis(hydroxymethyl)-3-quinuclidinone
CAS Number	5608-24-2
Molecular Formula	C₉H₁₅NO₃
Formula Weight	185.2
Formulation	A crystalline solid
Purity	>95%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OCC1(CO)N2CCC(CC2)C1=O

Background Reading

Bykov, V.J.N., Issaeva, N., Shilov, A., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 8(3) 282-288 (2002).

PRIMA-1 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$14.00		$0.00
5 mg	$56.00		$0.00
10 mg	$84.00		$0.00
50 mg	$280.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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