See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Xestospongin C

Cayman Chemical Item Number 64950

Araguspongine E; XeC (CAS 88903-69-9)

Xestospongin C (CAS 88903-69-9)

See more

Description

Xestospongin C is a marine natural product which was first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Xestospongin C antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Inositol phosphates are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 µM.2 Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700 nM.3

1 Nakagawa, M., and Endo, M. Structures of xestospongin A, B, C and D, novel vasodilative compounds from marine sponge, Xestospongia exigua. Tetrahedron Lett 25(30) 3227-3230 (1984).

2 Gafni, J., Munsch, J.A., Lam, T.H., et al. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron 19 723-733 (1997).

3 Castonguay, A., and Robitaille, R. Xestospongin C is a potent inhibitor of SERCA at a vertabrate synapse. Cell Calcium 32(1) 39-47 (2002).

Synonyms
  • Araguspongine E
  • XeC
Formal Name [1R-​(1R,​4aR,​11R,​12aS,​13S,​16aS,​23R,​24aS)]-​eicosahydro-​5H,​17H-​1,​23:11,​13-​diethano-​2H,​14H-​[1,​11]dioxacycloeicosino[2,​3-​b:12,​13-​b1]dipyridine
CAS Number 88903-69-9
Molecular Formula C28H50N2O2
Formula Weight 446.7
Formulation A clear film
Purity >90%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
C1CCC[C@H]​2CCCN3CCC(CCCCCCC4CCCN5CCC(CC1)​O[C@H]​45)​O[C@H]​23

Background Reading

Nakagawa, M., and Endo, M. Structures of xestospongin A, B, C and D, novel vasodilative compounds from marine sponge, Xestospongia exigua. Tetrahedron Lett 25(30) 3227-3230 (1984).

Gafni, J., Munsch, J.A., Lam, T.H., et al. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron 19 723-733 (1997).

Castonguay, A., and Robitaille, R. Xestospongin C is a potent inhibitor of SERCA at a vertabrate synapse. Cell Calcium 32(1) 39-47 (2002).
Size Price Quantity Subtotal
50 µg $280.00 $0.00
100 µg $532.00 $0.00
250 µg $1,260.00 $0.00
1 mg $3,920.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

2-APB
Araguspongin B
D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)
D-myo-Inositol-1,3,4-triphosphate (sodium salt)
D-myo-Inositol-1,4,5-triphosphate (potassium salt)
PtdIns-(4,5)-P2 (1,2-dioctanoyl) (sodium salt)
PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (ammonium salt)
SKF-96365 (hydrochloride)
Thapsigargin New
(+)-Xestospongin A
Show all 10 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

FAQs

What is the solubility of Xestospongin in water?

Xestospongin is only slightly soluble in aqueous solvents. It is suggested to first dissolve the compound in an organic solvent and then make dilutions with an aqueous solvent to get it into any type of aqueous solution.

Show answer Hide answer

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?