Cayman Chemical | CD95 (human) cDNA Probe | Description • Fas (human); Apo-1

660616 CD95 (human) cDNA Probe

Fas (human); Apo-1

• See below for pricing and ordering

• See analysis tools

• See more Molecular Biology; Apoptosis; Cancer

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

This probe is used for the detection of human Fas mRNA. Fas is a member of the family of cell surface receptors possessing a death domain. Binding of ligand to Fas results in a cascade of events culminating in apoptosis.¹ Northern blot analysis reveals two transcripts for Fas mRNA, 1.9 kb and 2.7 kb in length, which are likely the result of alternative splicing.² Treatment of HT-29 cells with IFNγ, or thyrocytes with IL-1β induces the expression of Fas.^3,2 This cDNA probe is 55% and 47% homologous to the corresponding murine and rat sequences, respectively.

1 Gamen, S., Anel, A., Piñeiro, A., et al. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell Death and Differentiation 5 241-249 (1998).

2 Itoh, N., Yonehara, S., Ishii, A., et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66 233-243 (1991).

3 Giordano, C., Stassi, G., De Maria, R., et al. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto’s thyroiditis. Science 275 960-963 (1997).

	Download Product Insert 93 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 660616 CD95 (human) cDNA Probe

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-15.
Prices are subject to change without notice.

Related Products