DPP (IV) Inhibitor Screening Assay Kit

Cayman Chemical Item Number 700210

DPP (IV) Inhibitor Screening Assay Kit

Description

DPP (IV) inhibitors have emerged as a new class of oral antidiabetic agents. These inhibitors promote glucose homeostasis by inhibiting degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by DPP (IV). GLP-1 extends the action of insulin while suppressing the release of glucagon. Cayman’s DPP (IV) Inhibitor Screening Assay provides a convenient fluorescence-based method for screening DPP (IV) inhibitors in a 96-well format.

Stability

1 year

Storage

-80°C

Shipping

Dry ice in continental US; may vary elsewhere

Background Reading

Durinx, C., Lambeir, A., Bosmans, E., et al. Molecular characterization of dipeptidyl peptidase activity in serum. Soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides. Eur J Biochem 267 5608-5613 (2000).

Mentlein, R. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul Pept 85 9-24 (1999).

Kikkawa, F., Kajiyama, H., Shibata, K., et al. Dipeptidyl peptidase IV in tumor progression. Biochim Biophys Acta 1751 45-51 (2005).

Morimoto, C., Lord, C.I., Zhang, C., et al. Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis. Proc Natl Acad Sci USA 91 9960-9964 (1994).

Fleischer, B. CD26: A surface protease involved in T-cell activation. Immunol Today 15(4) 180-184 (1994).

Heike, M., Möbius, U., Knuth, A., et al. Tissue distribution of the T cell activation antigen Ta1. Serological, immunohistochemical and biochemical investigations. Clin Exp Immunol 74 431-434 (1988).

Lambeir, A., Pereira, J.F.D., Chacón, P., et al. A prediction of DPP IV/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma. Biochim Biophys Acta 1340 215-226 (1997).

Langley, A.K., Suffoletta, T.J., and Jennings, H.R. Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 Diabetes Mellitus. Pharmacotherapy 27 1163-1180 (2007).

Doupis, J., and Veves, A. DPP4 inhibitors: A new approach in diabetes treatment. Adv Ther 25(7) 627-643 (2008).

Havre, P.A., Abe, M., Urasaki, Y., et al. The role of CD26/dipeptidyl peptidase IV in cancer. Front Biosci 13 1634-1645 (2008).

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700210-96well

Half Volume 96-Well Solid Plate (white)