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CAY10397

Cayman Chemical Item Number 70130

CK47A (CAS 78028-01-0)

CAY10397 (CAS 78028-01-0)

See more	Enzyme Activity (146) Inhibitors (493)

Description

Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC₅₀ of approximately 10 µM.¹ CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.

1 Berry, C.N., Hoult, J.R.S., Peers, S.H., et al. Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues. Biochem Pharmacol 32 2863-2871 (1983).

Synonyms	CK47A
Formal Name	5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid
CAS Number	78028-01-0
Molecular Formula	C₁₇H₁₆N₂O₅
Formula Weight	328.3
Formulation	A crystalline solid
Purity	>98%
λ_max	261, 370 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC1=C(CC(O)=O)C=C(N=NC2=CC=C(C(OCC)=O)C=C2)C=C1

Background Reading

Berry, C.N., Hoult, J.R.S., Peers, S.H., et al. Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues. Biochem Pharmacol 32 2863-2871 (1983).

CAY10397 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$46.00		$0.00
5 mg	$207.00		$0.00
10 mg	$368.00		$0.00
25 mg	$805.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

15-hydroxy Prostaglandin Dehydrogenase (human recombinant)

15(R)-Prostaglandin E₁

16,16-dimethyl Prostaglandin E₂

CAY10638 Exclusive

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Batch-specific Information

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