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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

LY83583

Cayman Chemical Item Number 70230

(CAS 91300-60-6)

LY83583 (CAS 91300-60-6)

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Description

LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 µM.1 LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 µM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 µM.2,3

1 Mülsch, A., Lückhoff, A., Pohl, U., et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol 340 119-125 (1989).

2 Fleisch, J.H., Haisch, K.D., Spaethe, S.M., et al. Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release. J Pharmacol Exp Ther 229 681-689 (1984).

3 Lüönd, R.M., McKie, J.H., and Douglas, K.T. A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism. Biochem Pharmacol 45 2547-2549 (1993).

Formal Name 6-​(phenylamino)-​5,​8-​quinolinedione
CAS Number 91300-60-6
Molecular Formula C15H10N2O2
Formula Weight 250.3
Formulation A crystalline solid
Purity >99%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1C=C(Nc2ccccc2)​C(=O)​c2cccnc12

Background Reading

Macleod, K.M., Ng, D.D.W., Harris, K.H., et al. Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to α-adrenoceptor stimulation. Mol Pharmacol 32 59-64 (1987).

Lüönd, R.M., McKie, J.H., and Douglas, K.T. A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism. Biochem Pharmacol 45 2547-2549 (1993).

Barbier, A.J.M., and Lefebvre, R.A. Effect of LY 83583 on relaxation induced non-adrenergic non-cholinergic nerve stimulation and exogenous nitric oxide in the rat gastric fundus. Eur J Pharmacol 219 331-334 (1992).

Kontos, H.A., and Wei, E.P. Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. Stroke 24 427-434 (1993).

Fleisch, J.H., Haisch, K.D., Spaethe, S.M., et al. Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release. J Pharmacol Exp Ther 229 681-689 (1984).

Mülsch, A., Lückhoff, A., Pohl, U., et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol 340 119-125 (1989).

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LY83583 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $13.00 $0.00
5 mg $52.00 $0.00
10 mg $78.00 $0.00
50 mg $260.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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