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Tacrine (hydrochloride)Cayman Chemical Item Number 70240 Romotal; Cognex (CAS 1684-40-8) 
Tacrine (hydrochloride) (CAS 1684-40-8)
Description
Tacrine is a derivative of aminoacridine which functions as an inhibitor of both AChE and butyrylcholinesterase.1 It has been used clinically in the treatment of Alzheimer’s disease.2,3 Tacrine also inhibits the uptake of serotonin and noradrenaline in rat cerebral cortex2,4 and decreases depolarization-
1 Crismon, M.L. Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer’s disease. Pharmacotherapy 18 47-54 (1998).
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Drukarch, B., Leysen, J.E., and Stoof, J.C. Further analysis of the neuropharmacological profile of 9- 3 Giacobini, E. Cholinesterase inhibitors for Alzheimer’s disease therapy: From tacrine to future applications. Neurochem Int 32 413-419 (1998).
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McKenna, M.T., Proctor, G.R., Young, L.C., et al. Novel tacrine analogues for potential use against Alzheimer’s disease: Potent and selective acetylcholinesterase inhibitors and 5- 5 Dolezal, V., Lisá, V., and Tucek, S. Effect of tacrine on intracellular calcium in cholinergic SN56 neuronal cells. Brain Res 769 219-224 (1997).
Background ReadingDrukarch, B., Leysen, J.E., and Stoof, J.C. Further analysis of the neuropharmacological profile of 9- Giacobini, E. Cholinesterase inhibitors for Alzheimer’s disease therapy: From tacrine to future applications. Neurochem Int 32 413-419 (1998). McKenna, M.T., Proctor, G.R., Young, L.C., et al. Novel tacrine analogues for potential use against Alzheimer’s disease: Potent and selective acetylcholinesterase inhibitors and 5- Crismon, M.L. Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer’s disease. Pharmacotherapy 18 47-54 (1998). Dolezal, V., Lisá, V., and Tucek, S. Effect of tacrine on intracellular calcium in cholinergic SN56 neuronal cells. Brain Res 769 219-224 (1997). Show all 5 Hide all but first 3Tacrine (hydrochloride) is available in the following screening library: |
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