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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

N-(4-acetamidophenyl)-Indomethacin amide

Cayman Chemical Item Number 70278

N-4AIA

N-(4-acetamidophenyl)-Indomethacin amide

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Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.1 N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 µM, respectively.1,2 It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

1 Kalgutkar, A.S., Marnett, A.B., Crews, B.C., et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem 43 2860-2870 (2000).

2 Johnson, J.L. . (1999).

Synonyms
  • N-4AIA
Formal Name N-​(4-​acetamidophenyl)-​1-​(4-​chlorobenzoyl)-​5-​methoxy-​2-​methyl-​1H-​indole-​3-​acetamide
Molecular Formula C27H24ClN3O4
Formula Weight 490.0
Formulation A crystalline solid
Purity ≥98%
λmax 267 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc2c(c1)​c(CC(=O)​Nc1ccc(cc1)​NC(=O)​C)​c(C)​n2C(=O)​c1ccc(Cl)​cc1

Background Reading

Kalgutkar, A.S., Crews, B.C., Rowlinson, S.W., et al. Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci USA 97 925-930 (2000).

Johnson, J.L. . (1999).

Kalgutkar, A.S., Marnett, A.B., Crews, B.C., et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem 43 2860-2870 (2000).

N-(4-acetamidophenyl)-Indomethacin amide is available in the following screening library:

Size Price Quantity Subtotal
1 mg $13.00 $0.00
5 mg $59.00 $0.00
10 mg $104.00 $0.00
50 mg $455.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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