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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(S)-Naproxen

Cayman Chemical Item Number 70290

(CAS 22204-53-1)

(S)-Naproxen (CAS 22204-53-1)

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Description

(S)-Naproxen is a non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively.1,2

1 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

2 Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 271 927-934 (1994).

Formal Name (S)-​6-​methoxy-​α-​methyl-​2-​naphthaleneacetic acid
CAS Number 22204-53-1
Molecular Formula C14H14O3
Formula Weight 230.3
Formulation A crystalline solid
Purity >99%
λmax 232, 272 nm
Stability 2 years
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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C[C@H]​(C(O)​=O)​C1=CC=C2C=C(OC)​C=CC2=C1

Background Reading

Harrison, I.T., Lewis, B., Nelson, P., et al. Nonsteroidal antiinflammatory agents. I. 6-Substituted 2-naphthylacetic acids. J Med Chem 13 203-205 (1970).

Zyglewska, T., Sanduja, R., Ohashi, K., et al. Inhibition of endothelial cell prostaglandin H synthase gene expression by naproxen. Biochim Biophys Acta 1131 78-82 (1992).

Jamali, F. Pharmacokinetics of enantiomers of chiral non-steroidal anti-inflammatory drugs. Eur J Drug Metab Pharmacokinet 13 1-9 (1988).

(S)-Naproxen is available in the following screening library:

Size Price Quantity Subtotal
1 g $8.00 $0.00
5 g $36.00 $0.00
25 g $140.00 $0.00
50 g $280.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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