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Nordihydroguaiaretic Acid

Cayman Chemical Item Number 70300

NDGA (CAS 500-38-9)

Nordihydroguaiaretic Acid (CAS 500-38-9)

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Description

NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM.1 The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.1,2

1 Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).

2 Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).

Synonyms
  • NDGA
Formal Name 4,​4'-​(2,​3-​dimethyl-​1,​4-​butanediyl)bis-​1,​2-​benzenediol
CAS Number 500-38-9
Molecular Formula C18H22O4
Formula Weight 302.4
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(Cc1ccc(O)​c(O)​c1)​C(C)​Cc1ccc(O)​c(O)​c1

Background Reading

Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).

Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).

Pavani, M., Fones, E., Oksenberg, D., et al. Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid. Biochem Pharmacol 48 1935-1942 (1994).

Tanaka, N., Espey, L.L., Kawano, T., et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol 260 E170-E174 (1991).

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Nordihydroguaiaretic Acid is available in the following screening library:

Size Price Quantity Subtotal
500 mg $22.00 $0.00
1 g $42.00 $0.00
5 g $176.00 $0.00
25 g $630.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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