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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Phenylbutazone

Cayman Chemical Item Number 70400

(CAS 50-33-9)

Phenylbutazone (CAS 50-33-9)

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Description

Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX.1 Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 µM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 µM for COX and prostacyclin synthase, respectively.1

1 Reed, G.A., Griffin, I.O., and Eling, T.E. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol 27 109-114 (1985).

Formal Name 4-​butyl-​1,​2-​diphenyl-​3,​5-​pyrazolidinedione
CAS Number 50-33-9
Molecular Formula C19H20N2O2
Formula Weight 308.4
Formulation A crystalline solid
Purity >99%
λmax 242 nm
Stability 2 years
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC1C(=O)​N(c2ccccc2)​N(c2ccccc2)​C1=O

Background Reading

Reed, G.A., Griffin, I.O., and Eling, T.E. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol 27 109-114 (1985).

Phenylbutazone is available in the following screening library:

Size Price Quantity Subtotal
1 g $10.00 $0.00
50 g $45.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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