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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Ozagrel

Cayman Chemical Item Number 70515

OKY-046 (CAS 82571-53-7)

Ozagrel (CAS 82571-53-7)

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Description

Inhibition of thromboxane synthase (TXAS), especially in human platelets, has been a clinical objective for many years. 1-Alkyl (N-alkyl)-imidazole derivatives have been recognized as TXAS inhibitors since the early 1980s.1,2,3 Ozagrel is a 1-alkyl imidazole derivative that acts as a selective inhibitor of TXAS with an IC50 of 11 nM. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke,4 and antihypertensive effects in spontaneously hypertensive rats.5

1 Iizuka, K., Akahane, K., Momose, D., et al. Highly selective inhibitors of thromboxane synthase. 1. Imidazole derivatives. J Med Chem 24 1139-1148 (1981 Nov 20).

2 Wright, W.B., Tomcufcik, A.S., Chan, P.S., et al. Thromboxane synthase inhibitors and antihypertensive agents. 4,N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones. J Med Chem 30 2277-2283 (1987 May 6).

3 Wright, W.B., Press, J.B., Chan, P.S., et al. Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-imidazol-1,2,4-triazol-1-yl)alkyl]aryl amides. J Med Chem 29 523-530 (1986).

4 Ichikawa, K., Tazawa, S., Hamano, S., et al. Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models. Pharmacology 59 257-265 (1999).

5 Press, J.B., Wright, W.B., Chan, P.S., et al. Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-Imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents. J Med Chem 29(5) 816-819 (1986).

Synonyms
  • OKY-046
Formal Name 3-​[4-​(1H-​imidazol-​1-​ylmethyl)phenyl]-​2E-​propenoic acid
CAS Number 82571-53-7
Molecular Formula C13H12N2O2
Formula Weight 228.3
Formulation A crystalline solid
Purity >98%
λmax 275 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​\C=C/c1ccc(cc1)​Cn1ccnc1

Background Reading

Ichikawa, K., Tazawa, S., Hamano, S., et al. Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models. Pharmacology 59 257-265 (1999).

Wright, W.B., Tomcufcik, A.S., Chan, P.S., et al. Thromboxane synthase inhibitors and antihypertensive agents. 4,N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones. J Med Chem 30 2277-2283 (1987 May 6).

Iizuka, K., Akahane, K., Momose, D., et al. Highly selective inhibitors of thromboxane synthase. 1. Imidazole derivatives. J Med Chem 24 1139-1148 (1981 Nov 20).

Wright, W.B., Press, J.B., Chan, P.S., et al. Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-imidazol-1,2,4-triazol-1-yl)alkyl]aryl amides. J Med Chem 29 523-530 (1986).

Press, J.B., Wright, W.B., Chan, P.S., et al. Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-Imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents. J Med Chem 29(5) 816-819 (1986).

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Ozagrel is available in the following screening library:

Size Price Quantity Subtotal
5 mg $27.00 $0.00
10 mg $51.00 $0.00
50 mg $216.00 $0.00
100 mg $378.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

1-Benzylimidazole
BM 567

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