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Ebselen

Cayman Chemical Item Number 70530

(CAS 60940-34-3)

Ebselen (CAS 60940-34-3)

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Description

Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 106 M−1s−1.1 The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at micromolar concentrations.2,3

1 Masumoto, H., Kissner, R., Koppenol, W.H., et al. Kinetic study of the reaction of ebselen with peroxynitrite. FEBS Lett 398 179-182 (1996).

2 Parnham, M.J., and Graf, E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem Pharmacol 36 3095-3102 (1987).

3 Parnham, M.J., and Kindt, S. A novel biologically active seleno-organic compound-III. Effects of PZ 51 (ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. Biochem Pharmacol 33 3247-3250 (1984).

Formal Name 2-​phenyl-​1,​2-​benzisoselenazol-​3(2H)-​one
CAS Number 60940-34-3
Molecular Formula C13H9NOSe
Formula Weight 274.2
Formulation A crystalline solid
Purity ≥99%
λmax 230, 263, 330 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=c1c2ccccc2[se]​n1c1ccccc1

Background Reading

Parnham, M.J., and Graf, E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem Pharmacol 36 3095-3102 (1987).

Parnham, M.J., and Kindt, S. A novel biologically active seleno-organic compound-III. Effects of PZ 51 (ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. Biochem Pharmacol 33 3247-3250 (1984).

Maiorino, M., Roveri, A., Coassin, M., et al. Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). Biochem Pharmacol 37 2267-2271 (1988).

Masumoto, H., Kissner, R., Koppenol, W.H., et al. Kinetic study of the reaction of ebselen with peroxynitrite. FEBS Lett 398 179-182 (1996).

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Ebselen is available in the following screening library:

Size Price Quantity Subtotal
5 mg $18.00 $0.00
10 mg $34.00 $0.00
50 mg $144.00 $0.00
100 mg $252.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

CAY10416
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MCI-186
MEG (sulfate)
ZLJ-6 Exclusive
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