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Ebselen

Cayman Chemical Item Number 70530

(CAS 60940-34-3)

Ebselen (CAS 60940-34-3)

See more	Antioxidants (62) Cyclooxygenase (97) Inhibitors (493) Oxidative Injury (258)

Description

Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 10⁶ M⁻¹s⁻¹.¹ The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at micromolar concentrations.^2,3

1 Masumoto, H., Kissner, R., Koppenol, W.H., et al. Kinetic study of the reaction of ebselen with peroxynitrite. FEBS Lett 398 179-182 (1996).

2 Parnham, M.J., and Graf, E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem Pharmacol 36 3095-3102 (1987).

3 Parnham, M.J., and Kindt, S. A novel biologically active seleno-organic compound-III. Effects of PZ 51 (ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. Biochem Pharmacol 33 3247-3250 (1984).

Formal Name	2-phenyl-1,2-benzisoselenazol-3(2H)-one
CAS Number	60940-34-3
Molecular Formula	C₁₃H₉NOSe
Formula Weight	274.2
Formulation	A crystalline solid
Purity	≥99%
λ_max	230, 263, 330 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=c1c2ccccc2[se]n1c1ccccc1

Background Reading

Parnham, M.J., and Graf, E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem Pharmacol 36 3095-3102 (1987).

Parnham, M.J., and Kindt, S. A novel biologically active seleno-organic compound-III. Effects of PZ 51 (ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. Biochem Pharmacol 33 3247-3250 (1984).

Maiorino, M., Roveri, A., Coassin, M., et al. Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). Biochem Pharmacol 37 2267-2271 (1988).

Masumoto, H., Kissner, R., Koppenol, W.H., et al. Kinetic study of the reaction of ebselen with peroxynitrite. FEBS Lett 398 179-182 (1996).

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Ebselen is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$18.00		$0.00
10 mg	$34.00		$0.00
50 mg	$144.00		$0.00
100 mg	$252.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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ZLJ-6 Exclusive

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Batch-specific Information

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