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Meclofenamate (sodium salt)

Cayman Chemical Item Number 70550

(CAS 6385-02-0)

Meclofenamate (sodium salt) (CAS 6385-02-0)

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Description

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.1

1 Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 271 927-934 (1994).

Formal Name 2-​[(2,​6-​dichloro-​3-​methylphenyl)amino]-​benzoic acid,​ monosodium salt
CAS Number 6385-02-0
Molecular Formula C14H10Cl2NO2 · Na
Formula Weight 318.1
Formulation A crystalline solid
Purity >99%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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Cc1ccccc1Nc1c(Cl)​ccc(C)​c1Cl

Background Reading

Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 271 927-934 (1994).

Meclofenamate (sodium salt) is available in the following screening library:

Size Price Quantity Subtotal
1 g $12.00 $0.00
5 g $54.00 $0.00
25 g $210.00 $0.00
50 g $420.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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