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Meclofenamate (sodium salt)

Cayman Chemical Item Number 70550

(CAS 6385-02-0)

Meclofenamate (sodium salt) (CAS 6385-02-0)

See more	Cyclooxygenase (97) Inhibitors (493)

Description

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC₅₀ values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC₅₀ is much lower if pre-incubated with the enzyme.¹

1 Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 271 927-934 (1994).

Formal Name	2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, monosodium salt
CAS Number	6385-02-0
Molecular Formula	C₁₄H₁₀Cl₂NO₂ · Na
Formula Weight	318.1
Formulation	A crystalline solid
Purity	>99%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Cc1ccccc1Nc1c(Cl)ccc(C)c1Cl

Background Reading

Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 271 927-934 (1994).

Meclofenamate (sodium salt) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 g	$12.00		$0.00
5 g	$54.00		$0.00
25 g	$210.00		$0.00
50 g	$420.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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