Caffeic acid is an inhibitor of 5-LO with an IC50 value of 3.7-72 µM and 12-LO with an IC50 value of 5.1-30 µM.1,2
1
Koshihara, Y., Neichi, T., Murota, S., et al. Caffeic acid is a selective inhibitor for leukotriene biosynthesis. Biochim Biophys Acta79292-97(1984).
2
Kohyama, N., Nagata, T., Fujimoto, S., et al. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci Biotechnol Biochem61347-350(1997).
Formal Name
3,4-dihydroxy cinnamic acid
CAS Number
331-39-5
Molecular Formula
C9H8O4
Formula Weight
180.2
Formulation
A crystalline solid
Purity
>97%
Stability
2 years
Storage
Room temperature
Shipping
Room temperature
in continental US; may vary elsewhere
SMILES
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OC(=O)\C=C/c1ccc(O)c(O)c1
Caffeic Acid is available in the following screening
library: