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Baicalein

Cayman Chemical Item Number 70610

(CAS 491-67-8)

Baicalein (CAS 491-67-8)

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Description

Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Several different functions of baicalein have been reported. Platelet 12-lipoxygenase is inhibited by baicalein with an ID50 value of 0.12 µM, with minimal inhibition of platelet cyclooxygenase-1 (IC50 = 0.83 mM).1 Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 µM.2 In addition to these effects, baicalein may play a role in apoptosis, as the compound inhibits cell growth of three human hepatocellular carcinoma cell lines with IC50 values ranging from 17-70 µg/ml.3

1 Sekiya, K., and Okuda, H. Selective inhibition of platelet lipoxygenase by baicalein. Biochem Biophys Res Commun 105 1090-1095 (1982).

2 Gao, D., Sakurai, K., Katoh, M., et al. Inhibition of microsomal lipid peroxidation by baicalein: A possible formation of an iron-baicalein complex. Biochem Mol Biol Int 39 215-225 (1996).

3 Matsuzaki, Y., Korokawa, N., Terai, S., et al. Cell death induced by baicalein in human hepatocellular carcinoma cell lines. Jpn J Cancer Res 87 170-177 (1996).

Formal Name 5,​6,​7-​trihydroxyflavone
CAS Number 491-67-8
Molecular Formula C15H10O5
Formula Weight 270.2
Formulation A yellow crystalline solid
Purity >95%
λmax 216, 277, 324 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1CC(Oc2cc(O)​c(O)​c(O)​c12)​c1ccccc1

Background Reading

Sekiya, K., and Okuda, H. Selective inhibition of platelet lipoxygenase by baicalein. Biochem Biophys Res Commun 105 1090-1095 (1982).

Gao, D., Sakurai, K., Katoh, M., et al. Inhibition of microsomal lipid peroxidation by baicalein: A possible formation of an iron-baicalein complex. Biochem Mol Biol Int 39 215-225 (1996).

Matsuzaki, Y., Korokawa, N., Terai, S., et al. Cell death induced by baicalein in human hepatocellular carcinoma cell lines. Jpn J Cancer Res 87 170-177 (1996).

Baicalein is available in the following screening library:

Size Price Quantity Subtotal
50 mg $13.00 $0.00
100 mg $25.00 $0.00
500 mg $104.00 $0.00
1 g $182.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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