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CAY10416

Cayman Chemical Item Number 70635

(CAS 443919-96-8)

CAY10416 (CAS 443919-96-8)

See more	Cyclooxygenase (97) Inhibitors (493) Lipoxygenase (84) Apoptosis (183) Cancer (606) Inflammation (383)

Description

Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC₅₀ values of 50 and 3 nM, respectively.¹ The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 µM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC₅₀ value of 83 µM.

1 Barbey, S., Goossens, L., Taverne, T., et al. Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. Bioorg Med Chem Lett 12 779-782 (2002).

Formal Name	3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
CAS Number	443919-96-8
Molecular Formula	C₂₉H₂₉FN₂O₅S
Formula Weight	536.6
Formulation	A crystalline solid
Purity	>95%
λ_max	204, 269 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COC1(CCOCC1)c1cc(OCc2cc(c3ccccc3)n(n2)c2ccc(cc2)S(=O)(=O)C)cc(F)c1

Background Reading

Barbey, S., Goossens, L., Taverne, T., et al. Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. Bioorg Med Chem Lett 12 779-782 (2002).

Size	Price	Quantity	Subtotal
1 mg	$43.00		$0.00
5 mg	$194.00		$0.00
10 mg	$344.00		$0.00
50 mg	$1,505.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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