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Nimesulide

Cayman Chemical Item Number 70640

R805 (CAS 51803-78-2)

Nimesulide (CAS 51803-78-2)

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Description

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.1,2

1 Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

2 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

Synonyms
  • R805
Formal Name N-​(4-​nitro-​2-​phenoxyphenyl)-​methanesulfonamide
CAS Number 51803-78-2
Molecular Formula C13H12N2O5S
Formula Weight 308.3
Formulation A crystalline solid
Purity >99%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=S(NC1=C(OC2=CC=CC=C2)​C=C([N+]​([O-]​)​=O)​C=C1)​(C)​=O

Background Reading

Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

Herndon, J.W., and Matasi, J.J. Hydrogenation of vinylogous esters. Tetrahedron Lett 33 5725-5728 (1992).

Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

Huff, R., Collins, P., Kramer, S., et al. A structural feature of N-[2-cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2). Inflamm Res 44 S145-S146 (1995).

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Nimesulide is available in the following screening library:

Size Price Quantity Subtotal
500 mg $8.00 $0.00
1 g $15.00 $0.00
5 g $64.00 $0.00
25 g $240.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

CAY10416
COX-1 (ovine)
COX Activity Assay Kit
COX Fluorescent Activity Assay Kit
NS-398
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