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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

DuP-697

Cayman Chemical Item Number 70645

(CAS 88149-94-4)

DuP-697 (CAS 88149-94-4)

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Description

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2.1 When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1.2 The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively.3 The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 µM.3 DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.4

1 Kargman, S., Wong, E., Greig, G.M., et al. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochem Pharmacol 52 1113-1125 (1996).

2 Seibert, K., Masferrer, J., Needleman, P., et al. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. Br J Pharmacol 117 1016-1020 (1996).

3 Johnson, J.L. . (2000).

4 Rosenstock, M., Danon, A., and Rimon, G. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Biochim Biophys Acta 1440 127-137 (1999).

Formal Name 5-​bromo-​2-​(4-​fluorophenyl)-​3-​(4-​(methylsulfonyl)phenyl)-​thiophene
CAS Number 88149-94-4
Molecular Formula C17H12BrFO2S2
Formula Weight 411.3
Formulation A crystalline solid
Purity ≥96%
λmax 254, 300 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Fc1ccc(cc1)​c1sc(Br)​cc1c1ccc(cc1)​S(=O)​(=O)​C

Background Reading

Kargman, S., Wong, E., Greig, G.M., et al. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochem Pharmacol 52 1113-1125 (1996).

Seibert, K., Masferrer, J., Needleman, P., et al. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. Br J Pharmacol 117 1016-1020 (1996).

Rosenstock, M., Danon, A., and Rimon, G. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Biochim Biophys Acta 1440 127-137 (1999).

Johnson, J.L. . (2000).

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DuP-697 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $102.00 $0.00
10 mg $194.00 $0.00
25 mg $459.00 $0.00
50 mg $816.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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