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Niflumic Acid

Cayman Chemical Item Number 70650

UP83; Nifluril; Donalgin; Actol (CAS 4394-00-7)

Niflumic Acid (CAS 4394-00-7)

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Description

Niflumic acid is a selective inhibitor of COX-2. The IC50 values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively.1 The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.2

1 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

2 Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

Synonyms
  • UP83
  • Nifluril
  • Donalgin
  • Actol
Formal Name 2-​[[3-​(trifluoromethyl)phenyl]amino]-​3-​pyridinecarboxylic acid
CAS Number 4394-00-7
Molecular Formula C13H9F3N2O2
Formula Weight 282.2
Formulation A crystalline solid
Purity >99%
λmax 225, 289, 340 nm
Stability 1 year
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​c1cccnc1Nc1cccc(c1)​C(F)​(F)​F

Background Reading

Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

Niflumic Acid is available in the following screening library:

Size Price Quantity Subtotal
5 g $16.00 $0.00
10 g $30.00 $0.00
50 g $128.00 $0.00
100 g $224.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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