Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Niflumic Acid

Cayman Chemical Item Number 70650

UP83; Nifluril; Donalgin; Actol (CAS 4394-00-7)

Niflumic Acid (CAS 4394-00-7)

See more	Cyclooxygenase (97) Inhibitors (493)

Description

Niflumic acid is a selective inhibitor of COX-2. The IC₅₀ values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively.¹ The K_i values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.²

1 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

2 Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

Synonyms	UP83 Nifluril Donalgin Actol
Formal Name	2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
CAS Number	4394-00-7
Molecular Formula	C₁₃H₉F₃N₂O₂
Formula Weight	282.2
Formulation	A crystalline solid
Purity	>99%
λ_max	225, 289, 340 nm
Stability	1 year
Storage	Room temperature
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F

Background Reading

Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

Niflumic Acid is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 g	$16.00		$0.00
10 g	$30.00		$0.00
50 g	$128.00		$0.00
100 g	$224.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

CAY10416

COX-1 (ovine)

COX-2 (ovine)

COX Activity Assay Kit

COX Fluorescent Activity Assay Kit

Nimesulide

NS-398

Show all 7 Hide all but first 3

Downloads

	Download Product Insert 123 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640