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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

SC-58125

Cayman Chemical Item Number 70655

(CAS 162054-19-5)

SC-58125 (CAS 162054-19-5)

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Description

SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.1 When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.2 In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM.3 It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.4

1 Seibert, K., Zhang, Y., Leahy, K., et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 91 12013-12017 (1994).

2 Anderson, G.D., Hauser, S.D., McGarity, K.L., et al. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest 97 2672-2679 (1996).

3 Miralpeix, M., Camacho, M., López-Belmonte, J., et al. Selective induction of cyclo-oxygenase-2 activity in the permanent human endothelial cell line HUV-EC-C: Biochemical and pharmacological characterization. Br J Pharmacol 121 171-180 (1997).

4 Sheng, H., Shao, J., Kirkland, S.C., et al. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99 2254-2259 (1997).

Formal Name 5-​(4-​fluorophenyl)-​1-​[4-​(methylsulfonyl)phenyl]-​3-​(trifluoromethyl)-​1H-​pyrazole
CAS Number 162054-19-5
Molecular Formula C17H12F4N2O2S
Formula Weight 384.3
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Seibert, K., Zhang, Y., Leahy, K., et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 91 12013-12017 (1994).

Anderson, G.D., Hauser, S.D., McGarity, K.L., et al. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest 97 2672-2679 (1996).

Miralpeix, M., Camacho, M., López-Belmonte, J., et al. Selective induction of cyclo-oxygenase-2 activity in the permanent human endothelial cell line HUV-EC-C: Biochemical and pharmacological characterization. Br J Pharmacol 121 171-180 (1997).

Sheng, H., Shao, J., Kirkland, S.C., et al. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99 2254-2259 (1997).

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Size Price Quantity Subtotal
1 mg $12.00 $0.00
5 mg $54.00 $0.00
10 mg $96.00 $0.00
25 mg $210.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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