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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Methyl α-Linolenyl Fluorophosphonate

Cayman Chemical Item Number 70662

MLnFP

Methyl α-Linolenyl Fluorophosphonate

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Description

Methyl α-linolenyl fluorophosphonate (MLnFP) is an analog of methyl arachidonyl fluorophosphonate (MAFP; Catalog No. 70660), which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand.1,2,3 The pharmacology of the α-linolenyl analog of MAFP has not been completely investigated.

1 Huang, Z., Liu, S., Street, I., et al. Methyl arachidonyl fluorophosphonate, a potent irreversible cPLA2 inhibitor, blocks the mobilization of arachidonic acid in human platelets and neutrophils. Mediators Inflamm 3 307-308 (1994).

2 Deutsch, D.G., Omeir, R., Arreaza, G., et al. Methyl arachidonyl fluorophosphonate: A potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol 53 255-260 (1997).

3 Lio, Y., Reynolds, L.J., Balsinde, J., et al. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta 1302 55-60 (1996).

Synonyms
  • MLnFP
Formal Name 9Z,​12Z,​15Z-​octadecatrienyl-​phosphonofluoridic acid,​ methyl ester
Molecular Formula C19H34FO2P
Formula Weight 344.4
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C/C=C\C/C=C\CCCCCCCCP(=O)​(F)​OC

Background Reading

Deutsch, D.G., Omeir, R., Arreaza, G., et al. Methyl arachidonyl fluorophosphonate: A potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol 53 255-260 (1997).

Huang, Z., Liu, S., Street, I., et al. Methyl arachidonyl fluorophosphonate, a potent irreversible cPLA2 inhibitor, blocks the mobilization of arachidonic acid in human platelets and neutrophils. Mediators Inflamm 3 307-308 (1994).

Lio, Y., Reynolds, L.J., Balsinde, J., et al. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta 1302 55-60 (1996).

Methyl α-Linolenyl Fluorophosphonate is available in the following screening library:

Size Price Quantity Subtotal
1 mg $66.00 $0.00
5 mg $297.00 $0.00
10 mg $528.00 $0.00
50 mg $2,310.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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