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Arachidonoyl Serotonin

Cayman Chemical Item Number 70665

AA-5HT (CAS 187947-37-1)

Arachidonoyl Serotonin (CAS 187947-37-1)

See more	Fatty Acid Amides (45) Neuroscience (654)

Description

Arachidonoyl serotonin is an inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of anandamide and other endogenous cannabinoids. It inhibits the FAAH activity isolated from mouse neuroblastoma cells with an IC₅₀ value of 12 µM. Both the K_m and the Vmax of the enzyme are affected, indicating the Arachidonoyl serotonin is a very tight binding, competitive inhibitor of FAAH. Arachidonoyl serotonin does not inhibit cPLA₂ and is essentially devoid of cannabimimetic activity.¹

1 Bisogno, T., Melck, D., De Petrocellis, L., et al. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun 248 515-522 (1998).

Synonyms	AA-5HT
Formal Name	N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
CAS Number	187947-37-1
Molecular Formula	C₃₀H₄₂N₂O₂
Formula Weight	462.7
Formulation	A solution in methyl acetate
Purity	>98%
λ_max	223, 278 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCc1c[nH]c2ccc(O)cc12

Background Reading

Bisogno, T., Melck, D., De Petrocellis, L., et al. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun 248 515-522 (1998).

Arachidonoyl Serotonin is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$29.00		$0.00
10 mg	$55.00		$0.00
50 mg	$232.00		$0.00
100 mg	$406.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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