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trans-Resveratrol

Cayman Chemical Item Number 70675

(E)-Resveratrol (CAS 501-36-0)

trans-Resveratrol (CAS 501-36-0)

See more	Antioxidants (62) Cyclooxygenase (97) Inhibitors (493) Atherosclerosis (323) Inflammation (383) Oxidative Injury (258)

Description

Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.^1,2,3 trans-Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.⁴ trans-Resveratrol is also a selective inhibitor of cyclooxygenase-1 (COX-1).⁵ It inhibits COX and peroxidase activities of COX-1 with ED₅₀ values of 15 and 3.7 µM, respectively; with essentially no inhibition of the COX activity of COX-2. Resveratrol also activates sirtuins⁶ and, in C. elegans, extends lifespan.⁷

1 Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

2 Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

3 Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pharmacol 123 1691-1699 (1998).

4 Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

5 Jang, M., Cai, L., Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 218-220 (1997).

6 Borra, M.T., Smith, B.C., and Denu, J.M. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 280(17) 17187-17195 (2005).

7 Howitz, K.T., Bitterman, K.J., Cohen, H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191-196 (2003).

Synonyms	(E)-Resveratrol
Formal Name	5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
CAS Number	501-36-0
Molecular Formula	C₁₄H₁₂O₃
Formula Weight	228.2
Formulation	A crystalline solid
Purity	>98%
λ_max	218, 307, 321 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1

Background Reading

Jang, M., Cai, L., Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 218-220 (1997).

Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pharmacol 123 1691-1699 (1998).

Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

Borra, M.T., Smith, B.C., and Denu, J.M. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 280(17) 17187-17195 (2005).

Howitz, K.T., Bitterman, K.J., Cohen, H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191-196 (2003).

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trans-Resveratrol is available in the following screening libraries:

Size	Price	Quantity	Subtotal
50 mg	$16.00		$0.00
100 mg	$30.00		$0.00
250 mg	$72.00		$0.00
500 mg	$128.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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