See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Bromoenol lactone

Cayman Chemical Item Number 70700

Haloenol lactone; HELSS; BEL (CAS 88070-98-8)

Bromoenol lactone (CAS 88070-98-8)

See more

Description

BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM.1 BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM).2,3

1 Hazen, S.L., Zupan, L.A., Weiss, R.H., et al. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. J Biol Chem 266 7227-7232 (1991).

2 Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270 445-450 (1995).

3 Daniels, S.B., Cooney, E., Sofia, M.J., et al. Haloenol lactones. Potent enzyme-activated irreversible inhibitors for α-chymotrypsin. J Biol Chem 258 15046-15053 (1983).

Synonyms
  • Haloenol lactone
  • HELSS
  • BEL
Formal Name 6E-​(bromomethylene)tetrahydro-​3-​(1-​naphthalenyl)-​2H-​pyran-​2-​one
CAS Number 88070-98-8
Molecular Formula C16H13BrO2
Formula Weight 317.2
Formulation A crystalline solid
Purity >98%
λmax 224 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
Br/C=C1\CCC(C(=O)​O\1)​c1cccc2ccccc12

Background Reading

Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270 445-450 (1995).

Daniels, S.B., Cooney, E., Sofia, M.J., et al. Haloenol lactones. Potent enzyme-activated irreversible inhibitors for α-chymotrypsin. J Biol Chem 258 15046-15053 (1983).

Hazen, S.L., Zupan, L.A., Weiss, R.H., et al. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. J Biol Chem 266 7227-7232 (1991).

Bromoenol lactone is available in the following screening library:

Size Price Quantity Subtotal
5 mg $96.00 $0.00
10 mg $182.00 $0.00
25 mg $432.00 $0.00
50 mg $768.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

EA4
Methyl Arachidonyl Fluorophosphonate
(R)-Bromoenol lactone Exclusive
(R)-Bromoenol lactone-d7 Exclusive
(S)-Bromoenol lactone
(S)-Bromoenol lactone-d7 Exclusive
sPLA2 Assay Kit
Show all 7 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?