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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Bromoenol lactone

Cayman Chemical Item Number 70700

Haloenol lactone; HELSS; BEL (CAS 88070-98-8)

Bromoenol lactone (CAS 88070-98-8)

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Description

BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM.1 BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM).2,3

1 Hazen, S.L., Zupan, L.A., Weiss, R.H., et al. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. J Biol Chem 266 7227-7232 (1991).

2 Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270 445-450 (1995).

3 Daniels, S.B., Cooney, E., Sofia, M.J., et al. Haloenol lactones. Potent enzyme-activated irreversible inhibitors for α-chymotrypsin. J Biol Chem 258 15046-15053 (1983).

Synonyms
  • Haloenol lactone
  • HELSS
  • BEL
Formal Name 6E-​(bromomethylene)tetrahydro-​3-​(1-​naphthalenyl)-​2H-​pyran-​2-​one
CAS Number 88070-98-8
Molecular Formula C16H13BrO2
Formula Weight 317.2
Formulation A crystalline solid
Purity >98%
λmax 224 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Br/C=C1\CCC(C(=O)​O\1)​c1cccc2ccccc12

Background Reading

Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270 445-450 (1995).

Daniels, S.B., Cooney, E., Sofia, M.J., et al. Haloenol lactones. Potent enzyme-activated irreversible inhibitors for α-chymotrypsin. J Biol Chem 258 15046-15053 (1983).

Hazen, S.L., Zupan, L.A., Weiss, R.H., et al. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. J Biol Chem 266 7227-7232 (1991).

Bromoenol lactone is available in the following screening library:

Size Price Quantity Subtotal
5 mg $96.00 $0.00
10 mg $182.00 $0.00
25 mg $432.00 $0.00
50 mg $768.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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