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U-75302

Cayman Chemical Item Number 70705

(CAS 119477-85-9)

U-75302 (CAS 119477-85-9)

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Description

U-75302 is an LTB4 receptor antagonist with a Ki of 159 nM on guinea pig lung membranes.1,2 This activity is specific for the BLT1 receptor; U-75302 does not antagonize the binding of [3H]-LTB4 to the human BLT2 receptor.3

1 Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J Pharmacol Exp Ther 255 565-571 (1990).

2 Lin, A.H., Morris, J., Wishka, D.G., et al. Novel molecules that antagonize leukotriene B4 binding to neutrophils. Ann N Y Acad Sci 524 196-200 (1988).

3 Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. J Biol Chem 275 40686-40694 (2000).

Formal Name 6-​(6-​(3R-​hydroxy-​1E,​5Z-​undecadien-​1-​yl)-​2-​pyridinyl)-​1,​5S-​hexanediol
CAS Number 119477-85-9
Molecular Formula C22H35NO3
Formula Weight 361.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OCCCC[C@H]​(O)​CC1=NC(/C=C/[C@H]​(O)​C/C=C\CCCCC)​=CC=C1

Background Reading

Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J Pharmacol Exp Ther 255 565-571 (1990).

Lin, A.H., Morris, J., Wishka, D.G., et al. Novel molecules that antagonize leukotriene B4 binding to neutrophils. Ann N Y Acad Sci 524 196-200 (1988).

Richards, I.M., Griffin, R.L., Oostveen, J.A., et al. Effect of the selective leukotriene B4 antagonist U-75302 on antigen-induced bronchopulmonary eosinophilia in sensitized guinea pigs. Annu Rev Respir Dis 140 1712-1716 (1989).

U-75302 is available in the following screening library:

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