LY171883 (CAS 88107-10-2) || Cayman Chemical

LY171883

Cayman Chemical Item Number 70710

(CAS 88107-10-2)

LY171883 (CAS 88107-10-2)

Description

LY171883 is a selective, potent, orally active antagonist of the leukotriene D₄ receptor.¹ Dissociation constants (KB) for LY171883 on guinea pig ileum and parenchyma are 0.07 and 0.34 µM, respectively.¹ LY171883 is an inhibitor of phosphodiesterase obtained from human polymorphonuclear leukocytes (IC₅₀ of 22.6 µM) and various guinea pig tissues (IC₅₀s range from 6.9-209 µM).¹ At a concentration of 50-100 µM, LY171883 binds to the PPARγ nuclear receptor, inducing adipogenesis in cultured NIH3T3 fibroblasts.^2,3

1 Fleisch, J.H., Rinkema, L.E., Haisch, K.D., et al. LY171883, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone, an orally active leukotriene D₄ antagonist. J Pharmacol Exp Ther 233 148-157 (1985).

2 Sala, A., Rossoni, G., Buccellati, C., et al. Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. Br J Pharmacol 110 1206-1212 (1993).

3 Tontonoz, P., Hu, E., and Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79 1147-1156 (1994).

Formal Name

1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]-ethanone

CAS Number

88107-10-2

Molecular Formula

C₁₆H₂₂N₄O₃

Formula Weight

318.4

Formulation

A crystalline solid

Purity

>98%

λ_max

218, 284 nm

Stability

2 years

Storage

Room temperature

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

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CCCc1c(OCCCCc2nnn[nH]2)ccc(C(=O)C)c1O

Background Reading

Fleisch, J.H., Rinkema, L.E., Haisch, K.D., et al. LY171883, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone, an orally active leukotriene D₄ antagonist. J Pharmacol Exp Ther 233 148-157 (1985).

Tontonoz, P., Hu, E., and Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79 1147-1156 (1994).

Sala, A., Rossoni, G., Buccellati, C., et al. Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. Br J Pharmacol 110 1206-1212 (1993).

Size

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