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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

BAY-u9773

Cayman Chemical Item Number 70770

(CAS 154978-38-8)

BAY-u9773 (CAS 154978-38-8)

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Description

The biological effects of the cysteinyl leukotrienes (cysLTs, including LTC4, LTD4, and LTE4) are transduced mainly by a pair of 7-transmembrane receptors, CysLT1 and CysLT2.1,2,3 BAY-u9773 is a non-selective antagonist of the CysLT receptors, having about the same IC50 (20-80 nM) for the inhibition of LT responses in a variety of tissue preparations containing either/or both receptors.4 In contrast, many of the commercially developed CysLT1 receptor antagonists (pranlukast or montelukast) antagonize only CysLT1 receptors. BAY-u9773 is thus one of the only available tools for blocking CysLT2 receptors.

1 Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

2 Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 275 30531-30536 (2000).

3 Ogasawara, H., Ishii, S., Yokomizo, T., et al. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2. Differential pharmacological properties and tissue distribution. J Biol Chem 277(21) 18763-18768 (2002).

4 Tudhope, S.R., Cuthbert, N.J., Abram, T.S., et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. Eur J Pharmacol 264 317-323 (1994).

Formal Name 4-​[[(1R,​2E,​4E,​6Z,​9Z)-​1-​[(1S)-​4-​carboxy-​1-​hydroxybutyl]-​2,​4,​6,​9-​pentadecatetraenyl]thio]-​benzoic acid
CAS Number 154978-38-8
Molecular Formula C27H36O5S
Formula Weight 472.6
Formulation A solution in ethanol
Purity >95%
λmax 279 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/[C@@H]​(Sc1ccc(cc1)​C(=O)​O)​C(O)​CCCC(=O)​O

Background Reading

Ogasawara, H., Ishii, S., Yokomizo, T., et al. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2. Differential pharmacological properties and tissue distribution. J Biol Chem 277(21) 18763-18768 (2002).

Tudhope, S.R., Cuthbert, N.J., Abram, T.S., et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. Eur J Pharmacol 264 317-323 (1994).

Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 275 30531-30536 (2000).

Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

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Size Price Quantity Subtotal
25 µg $46.00 $0.00
50 µg $87.00 $0.00
100 µg $166.00 $0.00
500 µg $736.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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