Cayman Chemical | Rosmarinic Acid | Description (CAS 20283-92-5)

70900 Rosmarinic Acid

(CAS 20283-92-5)

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Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 µg/ml.¹ Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin.^2,3 Formation of 5-HETE and LTB₄ from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M.⁴

1 Liu, G., Zhang, T., Wang, B., et al. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43 147-152 (1992).

2 Bult, H., Herman, A.G., Rampart, M. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. Br J Pharmacol 84 317-327 (1985).

3 Rampart, M., Beetens, J.R., Bult, H., et al. Complement-dependent stimulation of prostacyclin biosynthesis: Inhibition by rosmarinic acid. Biochem Pharmacol 35 1397-1400 (1986).

4 Kimura, Y., Okuda, H., Okuda, T., et al. Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. J Nat Prod 50 392-399 (1987).

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Pricing updated 2010-03-17.
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