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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Rosmarinic Acid

Cayman Chemical Item Number 70900

(CAS 20283-92-5)

Rosmarinic Acid (CAS 20283-92-5)

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Description

Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 µg/ml.1 Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin.2,3 Formation of 5-HETE and LTB4 from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M.4

1 Liu, G., Zhang, T., Wang, B., et al. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43 147-152 (1992).

2 Bult, H., Herman, A.G., and Rampart, M. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. Br J Pharmacol 84 317-327 (1985).

3 Rampart, M., Beetens, J.R., Bult, H., et al. Complement-dependent stimulation of prostacyclin biosynthesis: Inhibition by rosmarinic acid. Biochem Pharmacol 35 1397-1400 (1986).

4 Kimura, Y., Okuda, H., Okuda, T., et al. Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. J Nat Prod 50 392-399 (1987).

Formal Name (R)-​α-​[[3-​(3,​4-​dihydroxyphenyl)-​1-​oxo-​2E-​propenyl]oxy]-​3,​4-​dihydroxy-​benzenepropanoic acid
CAS Number 20283-92-5
Molecular Formula C18H16O8
Formula Weight 360.3
Formulation A crystalline solid
Purity >98%
λmax 221, 291, 332 nm
Stability 1 year
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=C(O)​C=CC(C[C@H]​(C(O)​=O)​OC(/C=C/C2=CC(O)​=C(O)​C=C2)​=O)​=C1

Background Reading

Bult, H., Herman, A.G., and Rampart, M. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. Br J Pharmacol 84 317-327 (1985).

Rampart, M., Beetens, J.R., Bult, H., et al. Complement-dependent stimulation of prostacyclin biosynthesis: Inhibition by rosmarinic acid. Biochem Pharmacol 35 1397-1400 (1986).

Kimura, Y., Okuda, H., Okuda, T., et al. Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. J Nat Prod 50 392-399 (1987).

Liu, G., Zhang, T., Wang, B., et al. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43 147-152 (1992).

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Rosmarinic Acid is available in the following screening library:

Size Price Quantity Subtotal
5 mg $12.00 $0.00
10 mg $23.00 $0.00
50 mg $96.00 $0.00
100 mg $168.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-09. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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