Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Rosmarinic Acid

Cayman Chemical Item Number 70900

(CAS 20283-92-5)

Rosmarinic Acid (CAS 20283-92-5)

See more	Antioxidants (62) Oxidative Injury (258)

Description

Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 µg/ml.¹ Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin.^2,3 Formation of 5-HETE and LTB₄ from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M.⁴

1 Liu, G., Zhang, T., Wang, B., et al. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43 147-152 (1992).

2 Bult, H., Herman, A.G., and Rampart, M. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. Br J Pharmacol 84 317-327 (1985).

3 Rampart, M., Beetens, J.R., Bult, H., et al. Complement-dependent stimulation of prostacyclin biosynthesis: Inhibition by rosmarinic acid. Biochem Pharmacol 35 1397-1400 (1986).

4 Kimura, Y., Okuda, H., Okuda, T., et al. Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. J Nat Prod 50 392-399 (1987).

Formal Name	(R)-α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
CAS Number	20283-92-5
Molecular Formula	C₁₈H₁₆O₈
Formula Weight	360.3
Formulation	A crystalline solid
Purity	>98%
λ_max	221, 291, 332 nm
Stability	1 year
Storage	Room temperature
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC1=C(O)C=CC(C[C@H](C(O)=O)OC(/C=C/C2=CC(O)=C(O)C=C2)=O)=C1

Background Reading

Bult, H., Herman, A.G., and Rampart, M. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. Br J Pharmacol 84 317-327 (1985).

Rampart, M., Beetens, J.R., Bult, H., et al. Complement-dependent stimulation of prostacyclin biosynthesis: Inhibition by rosmarinic acid. Biochem Pharmacol 35 1397-1400 (1986).

Kimura, Y., Okuda, H., Okuda, T., et al. Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. J Nat Prod 50 392-399 (1987).

Liu, G., Zhang, T., Wang, B., et al. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43 147-152 (1992).

Show all 4 Hide all but first 3

Rosmarinic Acid is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$12.00		$0.00
10 mg	$23.00		$0.00
50 mg	$96.00		$0.00
100 mg	$168.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-09. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

BHT

Carnosol

Celastrol

Curcumin

Curcumin (technical grade)

trans-Resveratrol

Show all 6 Hide all but first 3

Downloads

	Download Product Insert 145 Kb PDF
	Download Material Safety Data Sheet (MSDS) 69 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640