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Epigallocatechin Gallate

Cayman Chemical Item Number 70935

Tea catechin; EGCG (CAS 989-51-5)

Epigallocatechin Gallate (CAS 989-51-5)

See more	Antioxidants (63) Flavonoids (20) Oxidative Injury (291)

Description

Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.^1,2,3 Epigallocatechin gallate (EGCG) is a principle phenolic antioxidant found in a variety of plants, including green and black tea. EGCG inhibits cellular oxidation of low density lipoproteins.⁴ EGCG is readily detected in human and rat plasma at ng/ml levels following oral ingestion.⁵ ECGC inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine.⁶

1 Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

2 Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

3 Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

4 Yoshida, H., Ishikawa, T., Hosoai, H., et al. Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein. Biochem Pharmacol 58 1695-1703 (1999).

5 Nakagawa, K., and Miyazawa, T. Chemiluminescence - high-performance liquid chromatographic determination of tea catechin, (−)-epigallacatechin 3-gallate, at picomole levels in rat and human plasma. Anal Biochem 248 41-49 (1997).

6 Fiala, E.S., Sodum, R.S., Bhattacharya, M., et al. (−)-Epigallacatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine. Experientia 52 922-926 (1996).

Synonyms	Tea catechin EGCG
Formal Name	3,4-dihydro-5,7-dihydroxy-2R-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3R-yl-3,4,5-trihydroxy-benzoate
CAS Number	989-51-5
Molecular Formula	C₂₂H₁₈O₁₁
Formula Weight	458.4
Formulation	A crystalline solid
Purity	≥98%
λ_max	276 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c(O)c1

Background Reading

Fiala, E.S., Sodum, R.S., Bhattacharya, M., et al. (−)-Epigallacatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine. Experientia 52 922-926 (1996).

Nakagawa, K., and Miyazawa, T. Chemiluminescence - high-performance liquid chromatographic determination of tea catechin, (−)-epigallacatechin 3-gallate, at picomole levels in rat and human plasma. Anal Biochem 248 41-49 (1997).

Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

Yoshida, H., Ishikawa, T., Hosoai, H., et al. Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein. Biochem Pharmacol 58 1695-1703 (1999).

Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

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Epigallocatechin Gallate is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing

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Related Products

8-hydroxy-2-deoxy Guanosine Exclusive

8-hydroxy Guanosine

(+)-Catechin (hydrate)

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