Cayman Chemical | Celastrol (CAS 34157-83-0)

Celastrol

Cayman Chemical Item Number 70950

(CAS 34157-83-0)

Celastrol (CAS 34157-83-0)

Formal Name

3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid

CAS Number

34157-83-0

Molecular Formula

C₂₉H₃₈O₄

Formula Weight

450.6

Formulation

A crystalline solid

Purity

>98%

λ_max

253, 424 nm

Stability

2 years

Storage

-20°C

Shipping

WET ICE in continental US; may vary elsewhere

SMILES

O=C1C=C2C(=CC=C3[C@@]2(C)CCC2(C)[C@@H]4C[C@@](C)(CC[C@]4(C)CC[C@]32C)C(=O)O)C(=C1O)C

Description

A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health.^1,2,3 Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC₅₀ value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.⁴

1 Frémont, L., Belguendouz, L., Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

2 Johnson, J.L., Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

3 Miller, N.J., Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789-1789 (1995).

4 Sassa, H., Takaishi, Y., Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990).

Johnson, J.L., Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

Frémont, L., Belguendouz, L., Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

Miller, N.J., Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789-1789 (1995).

Sassa, H., Takaishi, Y., Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990).

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