A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health.^1,2,3 Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC₅₀ value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.⁴

1 Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

2 Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

3 Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

4 Sassa, H., Takaishi, Y., and Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990).

Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).

Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).

Sassa, H., Takaishi, Y., and Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990).

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Celastrol is available in the following screening library:

• Bio-active Lipid I Screening Library (96-Well)