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U-0126

Cayman Chemical Item Number 70970

(CAS 109511-58-2)

U-0126 (CAS 109511-58-2)

See more	Inhibitors (546) Signal Transduction (328)

Description

U-0126 is a selective MAP Kinase Kinase (MKK, MEK) inhibitor with IC₅₀ values of 72 nM and 58 nM for MEK1 and MEK2, respectively.¹ It shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, CDK2, and CDK4. U-0126 inhibition of MEK is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK, which may partially explain its selectivity profile against other kinases.¹

1 Favata, M.F., Horiuchi, K.Y., Manos, E.J., et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase*. J Biol Chem 273 (29) 18623-18632 (1998).

Formal Name	2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile
CAS Number	109511-58-2
Molecular Formula	C₁₈H₁₆N₆S₂
Formula Weight	380.5
Formulation	A crystalline solid
Purity	>98%
λ_max	247, 308 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard N/C(SC1=CC=CC=C1N)=C(C#N)\C(C#N)=C(N)\SC2=C(N)C=CC=C2

Background Reading

Favata, M.F., Horiuchi, K.Y., Manos, E.J., et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase*. J Biol Chem 273 (29) 18623-18632 (1998).

U-0126 is available in the following screening library:

Kinase Screening Library (96-Well)

Size	Global Purchasing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
25 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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