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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

2,4-DPD

Cayman Chemical Item Number 71200

2,4-Diethylpyridine dicarboxylate (CAS 41438-38-4)

2,4-DPD (CAS 41438-38-4)

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Description

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).1 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range.2 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.3,4

1 Jaakkola, P., Mole, D.R., Tian, Y., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468-472 (2001).

2 Friedman, L., Higgin, J.J., Moulder, G., et al. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proc Natl Acad Sci USA 97 4736-4741 (2000).

3 Bruick, R., and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 1337-1340 (2001).

4 Ivan, M., Kondo, K., Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 464-468 (2001).

Synonyms
  • 2,4-Diethylpyridine dicarboxylate
Formal Name 2,​4-​pyridinedicarboxylic acid,​ diethyl ester
CAS Number 41438-38-4
Molecular Formula C11H13NO4
Formula Weight 223.2
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(OCC)​C1=NC=CC(C(OCC)​=O)​=C1

Background Reading

Ivan, M., Kondo, K., Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 464-468 (2001).

Jaakkola, P., Mole, D.R., Tian, Y., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468-472 (2001).

Friedman, L., Higgin, J.J., Moulder, G., et al. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proc Natl Acad Sci USA 97 4736-4741 (2000).

Bruick, R., and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 1337-1340 (2001).

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2,4-DPD is available in the following screening libraries:

Size Price Quantity Subtotal
10 mg $14.00 $0.00
25 mg $33.00 $0.00
50 mg $63.00 $0.00
100 mg $112.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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