See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

DMOG

Cayman Chemical Item Number 71210

Dimethyloxallyl Glycine (CAS 89464-63-1)

DMOG (CAS 89464-63-1)

See more

Description

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).1 DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.1 DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.2,3

1 Jaakkola, P., Mole, D.R., Tian, Y., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468-472 (2001).

2 Bruick, R., and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 1337-1340 (2001).

3 Ivan, M., Kondo, K., Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 464-468 (2001).

Synonyms
  • Dimethyloxallyl Glycine
Formal Name N-​(methoxyoxoacetyl)-​glycine methyl ester
CAS Number 89464-63-1
Molecular Formula C6H9NO5
Formula Weight 175.1
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
COC(=O)​CNC(=O)​C(=O)​OC

Background Reading

Ivan, M., Kondo, K., Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 464-468 (2001).

Jaakkola, P., Mole, D.R., Tian, Y., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468-472 (2001).

Friedman, L., Higgin, J.J., Moulder, G., et al. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proc Natl Acad Sci USA 97 4736-4741 (2000).

Bruick, R., and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 1337-1340 (2001).

Show all 4 Hide all but first 3

DMOG is available in the following screening library:

Size Global Purchasing
10 mg See a distributor in your region for pricing
50 mg See a distributor in your region for pricing
100 mg See a distributor in your region for pricing
500 mg See a distributor in your region for pricing

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

1,4-DPCA
2,4-DPD
CAY10585
HIF-1α (C-Term) Polyclonal Antibody
HIF-1α Monoclonal Antibody (Clone H1α67)
IOX1 New
Show all 6 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?