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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

DMOG

Cayman Chemical Item Number 71210

Dimethyloxallyl Glycine (CAS 89464-63-1)

DMOG (CAS 89464-63-1)

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Description

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).1 DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.1 DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.2,3

1 Jaakkola, P., Mole, D.R., Tian, Y., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468-472 (2001).

2 Bruick, R., and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 1337-1340 (2001).

3 Ivan, M., Kondo, K., Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 464-468 (2001).

Synonyms
  • Dimethyloxallyl Glycine
Formal Name N-​(methoxyoxoacetyl)-​glycine methyl ester
CAS Number 89464-63-1
Molecular Formula C6H9NO5
Formula Weight 175.1
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COC(=O)​CNC(=O)​C(=O)​OC

Background Reading

Ivan, M., Kondo, K., Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 464-468 (2001).

Jaakkola, P., Mole, D.R., Tian, Y., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468-472 (2001).

Friedman, L., Higgin, J.J., Moulder, G., et al. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proc Natl Acad Sci USA 97 4736-4741 (2000).

Bruick, R., and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 1337-1340 (2001).

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DMOG is available in the following screening library:

Size Price Quantity Subtotal
10 mg $14.00 $0.00
50 mg $63.00 $0.00
100 mg $112.00 $0.00
500 mg $490.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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