Cayman Chemical | Oleoyl Oxazolopyridine | Description • CAY10400 (CAS 288862-58-8)

71650 Oleoyl Oxazolopyridine

CAY10400 (CAS 288862-58-8)

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Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Oleoyl oxazolopyridine is a potent inhibitor of FAAH exhibiting K_i values of 1.3 and 2.3 nM for the human and rat enzymes, respectively.¹ Oleoyl oxazolopyridine is approximately 35-fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions. Selectivity of oleoyl oxazolopyridine for FAAH versus cannabinoid receptors or PLA₂ has not been reported.

1 Boger, D.L., Sato, H., Lerner, A.E., et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide. Proc Natl Acad Sci USA 97 5044-5049 (2000).

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Pricing updated 2010-03-18.
Prices are subject to change without notice.

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