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Oleoyl Oxazolopyridine

Cayman Chemical Item Number 71650

CAY10400 (CAS 288862-58-8)

Oleoyl Oxazolopyridine (CAS 288862-58-8)

See more	Fatty Acid Amides (45) Neuroscience (654)

Description

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Oleoyl oxazolopyridine is a potent inhibitor of FAAH exhibiting K_i values of 1.3 and 2.3 nM for the human and rat enzymes, respectively.¹ Oleoyl oxazolopyridine is approximately 35-fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions. Selectivity of oleoyl oxazolopyridine for FAAH versus cannabinoid receptors or PLA₂ has not been reported.

1 Boger, D.L., Sato, H., Lerner, A.E., et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide. Proc Natl Acad Sci USA 97 5044-5049 (2000).

Synonyms	CAY10400
Formal Name	1-oxazolo[4,5-b]pyridin-2-yl-octadec-9Z-en-1-one
CAS Number	288862-58-8
Molecular Formula	C₂₄H₃₆N₂O₂
Formula Weight	384.6
Formulation	A solution in methyl acetate
Purity	>98%
λ_max	234, 297 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCC/C=C\CCCCCCCC(=O)c1nc2ncccc2o1

Background Reading

Boger, D.L., Sato, H., Lerner, A.E., et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide. Proc Natl Acad Sci USA 97 5044-5049 (2000).

Oleoyl Oxazolopyridine is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 µg	$28.00		$0.00
500 µg	$126.00		$0.00
1 mg	$224.00		$0.00
5 mg	$980.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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