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Ciglitazone

Cayman Chemical Item Number 71730

U-63287; ADD 3878 (CAS 74772-77-3)

Ciglitazone (CAS 74772-77-3)

See more	Nuclear Receptors (94) PPAR (59) Atherosclerosis (325) Diabetes (137) Endocrinology (337) Metabolism (145)

Description

Ciglitazone is an antidiabetic drug of the thiazolidinedione structural class. Ciglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with an EC₅₀ of 3.0 µM.¹ Ciglitazone is active in vivo as an anti-hyperglycemic agent in the ob/ob mouse model.¹

1 Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39 665-668 (1996).

Synonyms	U-63287 ADD 3878
Formal Name	5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS Number	74772-77-3
Molecular Formula	C₁₈H₂₃NO₃S
Formula Weight	333.4
Formulation	A crystalline solid
Purity	≥98%
λ_max	228, 279, 284 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCCCC1

Background Reading

Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39 665-668 (1996).

Ciglitazone is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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Rosiglitazone

Rosiglitazone (potassium salt)

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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