Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Ciglitazone

Cayman Chemical Item Number 71730

U-63287; ADD 3878 (CAS 74772-77-3)

Ciglitazone (CAS 74772-77-3)

See more	Nuclear Receptors (86) PPAR (59) Atherosclerosis (323) Diabetes (134) Endocrinology (335) Metabolism (139)

Description

Ciglitazone is an antidiabetic drug of the thiazolidinedione structural class. Ciglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with an EC₅₀ of 3.0 µM.¹ Ciglitazone is active in vivo as an anti-hyperglycemic agent in the ob/ob mouse model.¹

1 Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39 665-668 (1996).

Synonyms	U-63287 ADD 3878
Formal Name	5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS Number	74772-77-3
Molecular Formula	C₁₈H₂₃NO₃S
Formula Weight	333.4
Formulation	A crystalline solid
Purity	≥98%
λ_max	228, 279, 284 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCCCC1

Background Reading

Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39 665-668 (1996).

Ciglitazone is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$18.00		$0.00
5 mg	$81.00		$0.00
10 mg	$144.00		$0.00
50 mg	$630.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

15-deoxy-Δ^12,14-Prostaglandin J₂

PPARγ Polyclonal Antibody

Rosiglitazone

Rosiglitazone (potassium salt)

Show all 11 Hide all but first 3

Downloads

	Download Product Insert 86 Kb PDF
	Download Material Safety Data Sheet (MSDS) 15 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640