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CAY10415 Exclusive

Cayman Chemical Item Number 71748

(CAS 146062-49-9)

CAY10415 (CAS 146062-49-9)

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Description

CAY10415 is a potent, antidiabetic drug of the TZD structural class. When adminstered as a food admixture at 100 mg/kg for four days, CAY10415 effectively lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice.1 CAY10415 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.1

1 Tanis, S.P., Parker, T.T., Colca, J.R., et al. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. J Med Chem 39 5053-5063 (1996).

Formal Name 5-​[[4-​[2-​(5-​ethyl-​2-​pyridinyl)-​2-​oxoethoxy]phenyl]methyl]-​2,​4-​thiazolidinedione
CAS Number 146062-49-9
Molecular Formula C19H18N2O4S
Formula Weight 370.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCc1ccc(nc1)​C(=O)​COc1ccc(cc1)​CC1SC(=O)​NC1=O

Background Reading

Yki-Järvinen, H. Thiazolidinediones. N Engl J Med 351 1106-1118 (2004).

Tanis, S.P., Parker, T.T., Colca, J.R., et al. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. J Med Chem 39 5053-5063 (1996).
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