CAY10415 is a potent, antidiabetic drug of the TZD structural class. When adminstered as a food admixture at 100 mg/kg for four days, CAY10415 effectively lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice.1 CAY10415 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.1
1
Tanis, S.P., Parker, T.T., Colca, J.R., et al. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. J Med Chem395053-5063(1996).
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CCc1ccc(nc1)C(=O)COc1ccc(cc1)CC1SC(=O)NC1=O
Background Reading
Yki-Järvinen, H. Thiazolidinediones. N Engl J Med3511106-1118(2004).
Tanis, S.P., Parker, T.T., Colca, J.R., et al. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. J Med Chem395053-5063(1996).
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