Calcitriol

Calcitriol

Cayman Chemical Item Number 71820

1α,25-dihydroxy Vitamin D₃ (CAS 32222-06-3)

Calcitriol (CAS 32222-06-3)

Description

Calcitriol (1α,25-dihydroxy Vitamin D₃) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin.¹ Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D₃, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors.² The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.³

1 Kumar, R. Metabolism of 1,25-dihydroxyvitamin D₃. Physiol Rev 64(2) 478-505 (1984).

2 Bikle, D.D., Gee, E., Halloran, B., et al. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 74 1966-1971 (1984).

3 Portale, A.A., Halloran, B.P., and Morris, R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 83 1494-1499 (1989).

Synonyms

1α,25-dihydroxy Vitamin D3

Formal Name

9,10-secocholesta-5Z,7E,10(19)-triene-1α,3β,25-triol

CAS Number

32222-06-3

Molecular Formula

C₂₇H₄₄O₃

Formula Weight

416.6

Formulation

A crystalline solid

Purity

>97%

Stability

1 year

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

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O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@@]3([C@H](C)CCCC(C)(O)C)[H])([H])[C@]3(C)CCC\2

Background Reading

Bikle, D.D., Gee, E., Halloran, B., et al. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 74 1966-1971 (1984).

Portale, A.A., Halloran, B.P., and Morris, R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 83 1494-1499 (1989).

Kumar, R. Metabolism of 1,25-dihydroxyvitamin D₃. Physiol Rev 64(2) 478-505 (1984).

Size

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