71820  Calcitriol

1α,25-dihydroxy Vitamin D3 (CAS 32222-06-3)

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• See more Endocrinology; Nutrition/Diet

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin.1 Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors.2 The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.3
1  Kumar, R. Metabolism of 1,25-dihydroxyvitamin D3. Physiol Rev 64(2) 478-505 (1984).
2  Bikle, D.D., Gee, E., Halloran, B., et al. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 74 1966-1971 (1984).
3  Portale, A.A., Halloran, B.P., Morris, R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 83 1494-1499 (1989).


Purchase 71820 Calcitriol

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-13.
Prices are subject to change without notice.

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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