Cayman Chemical | Calcitriol | Description • 1α,25-dihydroxy Vitamin D3 (CAS 32222-06-3)

Cayman Chemical Company will be closed November 27 & 28 for Thanksgiving. Click for details.

71820 Calcitriol

1α,25-dihydroxy Vitamin D₃ (CAS 32222-06-3)

• See below for pricing and ordering

• See more Endocrinology; Nutrition/Diet

Calcitriol (1α,25-dihydroxy Vitamin D₃) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin.¹ Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D₃, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors.² The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.³

1 Kumar, R. Metabolism of 1,25-dihydroxyvitamin D₃. Physiol Rev 64(2) 478-505 (1984).

2 Bikle, D.D., Gee, E., Halloran, B., et al. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 74 1966-1971 (1984).

3 Portale, A.A., Halloran, B.P., Morris, R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 83 1494-1499 (1989).

	Download Product Insert 116 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 71820 Calcitriol

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2008-11-21.
Prices are subject to change without notice.

Related Products