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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Calcitriol

Cayman Chemical Item Number 71820

1α,25-dihydroxy Vitamin D3 (CAS 32222-06-3)

Calcitriol (CAS 32222-06-3)

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Description

Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin.1 Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors.2 The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.3

1 Kumar, R. Metabolism of 1,25-dihydroxyvitamin D3. Physiol Rev 64(2) 478-505 (1984).

2 Bikle, D.D., Gee, E., Halloran, B., et al. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 74 1966-1971 (1984).

3 Portale, A.A., Halloran, B.P., and Morris, R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 83 1494-1499 (1989).

Synonyms
  • 1α,25-dihydroxy Vitamin D3
Formal Name 9,​10-​secocholesta-​5Z,​7E,​10(19)-​triene-​1α,​3β,​25-​triol
CAS Number 32222-06-3
Molecular Formula C27H44O3
Formula Weight 416.6
Formulation A crystalline solid
Purity >97%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​(C[C@H]​(O)​C/1=C)​CC1=C\C=C2[C@@]​(CC[C@@]​3([C@H]​(C)​CCCC(C)​(O)​C)​[H]​)​([H]​)​[C@]​3(C)​CCC\2

Background Reading

Bikle, D.D., Gee, E., Halloran, B., et al. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 74 1966-1971 (1984).

Portale, A.A., Halloran, B.P., and Morris, R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 83 1494-1499 (1989).

Kumar, R. Metabolism of 1,25-dihydroxyvitamin D3. Physiol Rev 64(2) 478-505 (1984).

Calcitriol is available in the following screening library:

Size Price Quantity Subtotal
1 mg $65.00 $0.00
5 mg $293.00 $0.00
10 mg $520.00 $0.00
100 mg $3,900.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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