Hyperforin (CAS 11079-53-1) || Cayman Chemical

Hyperforin

Cayman Chemical Item Number 75650

(CAS 11079-53-1)

Hyperforin (CAS 11079-53-1)

Description

St. John’s wort is a widely consumed herbal preparation which has been claimed to have a number of medicinal properties. It contains a number of known lipid signalling mediators, including chlorogenic acid, hypericin, hyperforin, and I₃,II8-biapigenin. Hyperforin exhibits two activities which may alter the action of other concurrent medications. It inhibits the activity of several CYP450 enzymes, with CYP2D6 being the most sensitive with an IC₅₀ of about 10 µg/ml.¹ Hyperforin is also a ligand for the steroid X receptor (SXR).² Since one activity of this receptor is the induction of CYP450 expression, the exact nature of hyperforin’s drug-drug interactions must be evaluated on a case-by-case basis. However, these interactions certainly complicate its use as a human therapeutic.

1 Obach, R.S. Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 294(1) 88-95 (2000).

2 Wentworth, J.M., Agostini, M., Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 166 R11-R16 (2000).

Formal Name

5-hydroxy-6R-methyl-1R,3,7S-tris(3-methyl-2-butenyl)-5S-(2-methyl-1-oxopropyl)-6R-(4-methyl-3-pentenyl)-bicyclo[3.3.1]non-3-ene-2,9-dione

CAS Number

11079-53-1

Molecular Formula

C₃₅H₅₂O₄

Formula Weight

536.8

Formulation

A solution in methanol

Purity

≥90%

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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CC(=CCC[C@]1(C)[C@@H](CC=C(C)C)CC2C(=O)C(=C(O)C1(C(=O)C(C)C)C2=O)CC=C(C)C)C

Background Reading

Chatterjee, S.S., Bhattacharya, S.K., Wonnemann, M., et al. Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci 63 499-510 (1998).

Wentworth, J.M., Agostini, M., Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 166 R11-R16 (2000).

Obach, R.S. Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 294(1) 88-95 (2000).

Size

Global Purchasing

25 µg 
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50 µg 
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100 µg 
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1 mg 
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