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Mn(III)TMPyP

Cayman Chemical Item Number 75852

Mn(III)TMPyP

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Description

Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst.1 SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M−1s−1 and ~2 x 106 M−1s−1, respectively.1,2 Mn(III)TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.2

1 Hunt, J., Lee, J., and Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chem Biol 4 845-858 (1997).

2 Faulkner, K.M., Liochev, S.I., and Fridovich, I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 269 23471-23476 (1994).

Formal Name Mn(III)tetrakis(1-​methyl-​4-​pyridyl)porphyrin pentachloride
Molecular Formula C44H36MnN8 · 5Cl
Formula Weight 909.0
Formulation A black crystalline solid
Purity >95%
λmax 455 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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C[n]​1ccc(cc1)​C1=c2ccc3C(=c4ccc5=C(c6cc[n]​(C)​cc6)​c6ccc7=C(c8cc[n]​(C)​cc8)​c8ccc1n8[Mn]​([n]​23)​([n]​67)​n45)​c1cc[n]​(C)​cc1

Background Reading

Hunt, J., Lee, J., and Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chem Biol 4 845-858 (1997).

Faulkner, K.M., Liochev, S.I., and Fridovich, I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 269 23471-23476 (1994).
Size Global Purchasing
10 mg See a distributor in your region for pricing
25 mg See a distributor in your region for pricing
50 mg See a distributor in your region for pricing
100 mg See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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